Starting SPRAVATO®

Begin a new day: starting your adult patients on SPRAVATO®

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Considerations for effective referrals for adult patients with TRD

Identify your adult patients who may be appropriate for SPRAVATO®, and follow the below steps for a possible referral:


TALK to your patient about SPRAVATO®1

Educate your patients on what SPRAVATO® does, the potential benefits and risks, and the need for visiting a certified SPRAVATO® treatment center. Also offer them a Medication Guide.


HELP your patient choose a certified SPRAVATO® treatment center

Coordinate care, make the referral, and consider scheduling your patient’s first appointment.


SHARE all relevant patient information with the certified SPRAVATO® treatment center

Be sure to provide your contact details as well as all relevant patient, clinical, and insurance information.

Read the Effective Referrals Guide to help support your patient’s treatment journey.

Locate a certified 
SPRAVATO® treatment center

Once you’ve decided SPRAVATO® may be an option for your adult patients with TRD, help them locate a certified SPRAVATO® treatment center in one of 2 ways:


Monday–Friday, 8:00 AM to 8:00 PM ET

call Janssen Carepath
becoming rems certified spravato

Becoming a REMS-certified 
SPRAVATO® treatment center

Learn more from physicians currently treating adult patients with TRD in operational certified treatment centers.

These healthcare providers have been compensated by Janssen Pharmaceuticals, Inc., for their participation in the video.

For practices interested in becoming a certified SPRAVATO® treatment center, consider the following:

REMS goals

Treatment centers must comply with full SPRAVATO® REMS requirements. For full REMS requirements, visit or call 855-382-6022


SPRAVATO® is a Schedule III controlled substance

Treatment center protocols should be followed for handling Schedule III products in accordance with federal, state, and local regulations


SPRAVATO® treatment requires the ability and capacity for scheduling frequent appointments


SPRAVATO® treatment requires staff and equipment to provide appropriate patient monitoring

For more information, please visit

1. SPRAVATO® [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc. July 2020.