Dosing and Administration

Dosing and Administration

What patients can expect when taking SPRAVATO®

Dosing SPRAVATO®1

In Study 2 (long-term), 39% of patients received the 56-mg dose, and 61% received the 84-mg dose of SPRAVATO®

SPRAVATO® does not require daily dosing and should be administered in conjunction with an oral AD

Careful consideration is advised prior to treatment of individuals with a history of substance use disorder, including alcohol. Monitoring for signs of abuse and dependence is recommended.

*Dosing frequency should be individualized to the lowest frequency required to maintain remission/response.

As determined by the prescribing physician.

SPRAVATO® administration1

SPRAVATO® should be self-administered by the patient under the supervision of a healthcare professional in a certified SPRAVATO® treatment center

The Day 1 starting dose of SPRAVATO® is 56 mg (2 devices).

Each single-use device contains 2 sprays, 1 spray for each nostril.

Dosing step3

Wait 5 minutes after each device to allow medication to absorb.

For patients requiring an 84-mg dose, taken only after an initial starting dose of 56 mg, use 3 devices.

Dosage adjustments should be made based on efficacy and tolerability of the previous dose

Read the full Dosing & Administration Resource before training and supervising patients.

Please see "Dosing and Administration" and "Instructions for Use" in the full Prescribing Information.

Learn more about the patient experience with SPRAVATO®

Post-administration observation and discharge

Healthcare provider observation for at least 2 hours will be required
  • Because of the possibility of delayed or prolonged sedation or dissociation in some cases, patients must be monitored by a healthcare professional for at least 2 hours following each treatment
Patients will require transportation from the treatment center
  • Caution patients that SPRAVATO® may impair their ability to drive, and not to engage in potentially hazardous activities requiring complete mental alertness and motor coordination, such as driving a motor vehicle or operating machinery, until the next day after a restful sleep
Reference

1.SPRAVATO® [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc. February 2020.